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Israeli bombardment of Gaza’s largest refugee camp killed and wounded hundreds of people—many of them women and children—on Tuesday, Palestinian officials said.

Ahmad al-Kahlout, a spokesperson for Gaza’s Interior Ministry, told reporters that the attack “completely destroyed” the Jabalia refugee camp in the northern Gaza Strip. Jabalia, along with the nearby al-Shati refugee camp, is located in an Israeli-designated evacuation zone.

“These buildings house hundreds of citizens. The occupation’s air force destroyed this district with six U.S.-made bombs,” said al-Kahlout. “It is the latest massacre caused by Israeli aggression on the Gaza Strip.”

The director of the nearby Indonesian Hospital said at least 50 people were killed in the strike.

A separate Israeli strike on a home in the al-Shati camp on Tuesday killed at least 10 people, Palestinian media reported.